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OHMSETT TRAINS OIL SPILL RESPONDERS
2001
International Oil Spill Conference Proceedings
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Ohmsett -The National Oil Spill Response Test Facility, located in Leonardo, New Jersey, is dedicated to providing independent and objective performance testing of full-scale oil spill response equipment; improving technologies through research and development; and for providing realistic training to response personnel. The U.S. Minerals Management Service manages the facility as part of its mandated requirements by the Oil Pollution Act (OPA) '90 to ensure that the best and safest technologies
doi:10.7901/2169-3358-2001-2-1021
fatcat:saq2hrc2qjhingisjvmkjmcwsq
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... are used in offshore oil and gas operations and emergency response. Ohmsett focuses on technical, classroom, and hands-on training for spill response personnel and prepares responders with the most realistic full-scale training before an actual spill. In partnership with the United States Coast Guard (USCG), Texas A&M University National Spill Control School, and SL Ross Environmental Research Ltd., Ohmsett has developed a comprehensive course program that includes: USCG Class C Response Technician training, Oil Spill Response and Strategies Training (in English and Spanish), and Dispersant Training for the Oil Spill Responder. Each course emphasizes classroom exercises and practical hands-on use of the oil spill equipment and technologies in realistic conditions. Classroom exercises are performed under the direction of certified industrial hygienists and experienced emergency responders. The program also incorporates the National Incident Management Systems (NIMS) Incident Command Systems (ICS) training. Following classroom instruction, students receive hands-on training in the tank where they practice recovering real oil, with full-scale spill equipment used in the field, under conditions that simulate an actual oil spill. During all tank exercises, students train with a variety of oils ranging from light and medium fuel oils, to heavy viscosity refined oils, as well as crudes and emulsified oils. At the completion of the tank exercises, students review their oil recovery efficiencies and critique their videotaped performances. Recovered oil is evaluated in terms of Oil Recovery Efficiency (ORE) and Throughput Efficiency (TE). A high ORE score is good and indicates that the skimmer and the operator have recovered mostly oil, as compared to water. A high TE score is good and indicates that the skimmer and the operator have recovered most of the oil spilled. These factors are used throughout the week to measure the student's increase in proficiency and to determine the overall effectiveness of the training course.
Control of mitochondrial protein import by pH
2003
FEBS Letters
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Protein import into mitochondria is inhibited by protons (IC 50 pH 6.5). The channels of the import machinery were examined to further investigate this pH dependence. TOM and TIM23 are the protein translocation channels of the mitochondrial outer and inner membranes, respectively, and their single channel behaviors at various pHs were determined using patchclamp techniques. While not identical, increasing H + concentration decreases the open probability of both TIM23 and TOM channels. The
doi:10.1016/s0014-5793(03)01012-3
pmid:14550566
fatcat:r2qmgep7wnd35arfd6ujmohtim
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... n of the pH dependences of protein import and channel properties suggests TIM23 open probability can limit import of nuclear-encoded proteins into the matrix of yeast mitochondria. ß
Nursing Support for Family Members of Critically Ill Adults
2007
Qualitative Health Research
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Researchers have identified the needs of family members of critically ill adults, explored their experiences, and investigated interventions. To address a gap in the theoretical knowledge about how nurses help these individuals, the authors developed a grounded theory of nursing support from the perspective of family members. Results indicated that family members were initiated into a cycle of Work to meet perceived responsibilities to Get Through the experience. Supportive nurses engaged in
doi:10.1177/1049732307308974
pmid:17968038
fatcat:7fre73vhgrh37pi6g4pwldvxzm
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... process of Lightening Our Load to mitigate the negative effects of the critical care experience on family members by Engaging With Us, Sustaining Us, and Disengaging From Us. No previous research has yet identified the Work of these family members, the steps they take to gain nurses' respect, and the significance to them of nurses' Welcoming us and Saying goodbye. This theory extends the understanding of nursing support beyond current knowledge of family needs, caring, comfort, supportive care, and social support.
Protein translocation across mitochondrial membranes: What a long, strange trip it is
1995
Cell
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For example,
M/Ml 7 was identified
as a
high copy
suppressor
of a mas6 (Mim23p)
mutant
(Ryan
and
Jensen,
1994). ...
Furthermore,
Mim23p
can be coprecipitated
with
at least two other
proteins,
each of which
can be cross-
linked to an arrested
precursor
(Ryan
and Jensen,
1993). ...
doi:10.1016/0092-8674(95)90089-6
pmid:7585952
fatcat:oh7j7vvotbhbtb3uyxgdr72cp4
HPP784299_Supplemental_Appendix_1 – Supplemental material for Using a Systems Approach to Achieve Impact and Sustain Results
2018
Figshare
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Zurcher, Jon Jensen and Ann Mansfield in Health Promotion Practice ...
Supplemental material, HPP784299_Supplemental_Appendix_1 for Using a Systems Approach to Achieve Impact and Sustain Results by Laurie Lachance, Theresa Kowalski-Dobson, Kathleen A. ...
Question guide developed by Kathleen A. Zurcher. For more information contact her at kzurcher33@gmail.com ...
doi:10.25384/sage.7048229.v1
fatcat:z4wcryktnbgn7ku4hiv5ykzw5q
Computer-aided detection of brain tumor invasion using multiparametric MRI
2009
Journal of Magnetic Resonance Imaging
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Purpose-To determine the potential of using a computer-aided detection method to intelligently distinguish peritumoral edema alone from peritumor edema consisting of tumor using a combination of high-resolution morphological and physiological magnetic resonance imaging (MRI) techniques available on most clinical MRI scanners. Materials and Methods-This retrospective study consisted of patients with two types of primary brain tumors: meningiomas (n=7) and glioblastomas (n=11). Meningiomas are
doi:10.1002/jmri.21878
pmid:19711398
pmcid:PMC4321878
fatcat:2x3iz443z5f5vaep356mkp3rn4
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... ically benign and have a clear delineation of tumor and edema. Glioblastomas are known to invade outside the contrast-enhancing area. Four classifiers of differing designs were trained using morphological, diffusion-weighted, and perfusion-weighted features derived from MRI to discriminate tumor and edema, tested on edematous regions surrounding tumors, and assessed for their ability to detect nonenhancing tumor invasion. Results-The four classifiers provided similar measures of accuracy when applied to the training and testing data. Each classifier was able to identify areas of non-enhancing tumor invasion supported with adjunct images or follow-up studies. Conclusion-The combination of features derived from morphological and physiological imaging techniques contains the information necessary for computer-aided detection of tumor invasion and allows for the identification of tumor invasion not previously visualized on morphological, diffusion-weighted, and perfusion-weighted images and maps. Further validation of this approach requires obtaining spatially co-registered tissue samples in a study with a larger sample size.
A Longitudinal Analysis of Stepfamily Relationship Quality and Adolescent Physical Health
2017
Journal of Adolescent Health
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Jensen Dashed lines indicate non-significant paths. ...
Jensen Results from the Vuong test supported the use of a zero-inflated model over a standard negative binomial model (z = 1.61, p = .05). OR = odds ratio; IRR = incidence rate ratio. ...
doi:10.1016/j.jadohealth.2017.04.015
pmid:28732714
pmcid:PMC5646364
fatcat:qtaosgbvjncv3ayzxc7fw3vxky
HPP784299_Supplemental_Appendix_2 – Supplemental material for Using a Systems Approach to Achieve Impact and Sustain Results
2018
Figshare
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Zurcher, Jon Jensen and Ann Mansfield in Health Promotion Practice ...
Supplemental material, HPP784299_Supplemental_Appendix_2 for Using a Systems Approach to Achieve Impact and Sustain Results by Laurie Lachance, Theresa Kowalski-Dobson, Kathleen A. ...
doi:10.25384/sage.7048232
fatcat:iv4wdhitkfh5vi5bkoepw5kb6m
Mechanism of Actin Network Stabilization by Changes in Polymer Flexibility by Calponin
2014
Biophysical Journal
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1 , Cynthia Gallant 2 , Kathleen Morgan 2 , David Weitz 1 , Jeffrey Moore 2 . 1 Harvard University, Cambridge, MA, USA, 2 Boston University, Boston, MA, USA. ...
Representative stress-strain curve shown below:
838-Pos Sunday, February 16, 2014 165a Board B593 Mechanism of Actin Network Stabilization by Changes in Polymer Flexibility by Calponin Eliza Morris 1 , Mikkel Jensen ...
doi:10.1016/j.bpj.2013.11.942
fatcat:cxdwl7avbvggvi7qukr6hv4s7q
"Set it and Forget it": Women's Perceptions and Opinions of Long-Acting Topical Vaginal Gels
2013
Aids and Behavior
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Women's initial understandings and anticipated acceptability of long-acting vaginal gels as potential anti-HIV microbicides was investigated by exploring the perceptibility variables associated with prototype formulations. Four focus groups with 29 women, aged 18-45, were conducted to consider gel prototypes with varied physicochemical and rheological properties. Participants responded favorably to the concept of long-acting vaginal gels as microbicides. Distinctions in understandings and
doi:10.1007/s10461-013-0652-4
pmid:24248674
pmcid:PMC4018755
fatcat:xwd3lhj2zzaljmiad23pzdqrva
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... needs regarding product dosing, characteristics, and effectiveness offer valuable insights into product design. Long-acting vaginal gels capable of protecting against HIV/STIs will be a viable option among potential users, with dosing frequency being an important factor in willingness to use.
The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever
2007
Genome Biology
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Wahl-Jensen and coworkers [40] recently showed that the virus-like particle induced decrease in endothelial barrier function was further enhanced by TNFα, which is known to induce a long-lasting decrease ...
doi:10.1186/gb-2007-8-8-r174
pmid:17725815
pmcid:PMC2375004
fatcat:6ljfhmafpfeoxa2z4u6lu7abyu
Mechanism of Calponin Stabilization of Cross-Linked Actin Networks
2014
Biophysical Journal
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The actin-binding protein calponin has been previously implicated in actin cytoskeletal regulation and is thought to act as an actin stabilizer, but the mechanism of its function is poorly understood. To investigate this underlying physical mechanism, we studied an in vitro model system of cross-linked actin using bulk rheology. Networks with basic calponin exhibited a delayed onset of strain stiffening (10.0% without calponin, 14.9% with calponin) and were able to withstand a higher maximal
doi:10.1016/j.bpj.2013.12.042
pmid:24559982
pmcid:PMC3944828
fatcat:v5izmh3xk5g7tptfcpv6bz6gg4
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... ain before failing (35% without calponin, 56% with calponin). Using fluorescence microscopy to study the mechanics of single actin filaments, we found that calponin increased the flexibility of actin filaments, evident as a decrease in persistence length from 17.6 mm without to 7.7 mm with calponin. Our data are consistent with current models of affine strain behavior in semiflexible polymer networks, and suggest that calponin stabilization of actin networks can be explained purely by changes in single-filament mechanics. We propose a model in which calponin stabilizes actin networks against shear through a reduction of persistence length of individual filaments.
GanedenBC30™ cell wall and metabolites: anti-inflammatory and immune modulating effects in vitro
2010
BMC Immunology
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Jensen et al. BMC Immunology 2010, 11:15 http://www.biomedcentral.com/1471-2172/11/15
Jensen et al. BMC Immunology 2010, 11:15 http://www.biomedcentral.com/1471-2172/11/15 Page 11 of 14 ...
doi:10.1186/1471-2172-11-15
pmid:20331905
pmcid:PMC2858026
fatcat:sagfe62l4zedhg5ru6hzskw2je
Age associations with neural processing of reward anticipation in adolescents with bipolar disorders
2016
NeuroImage: Clinical
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Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy
doi:10.1016/j.nicl.2016.03.013
pmid:27114896
pmcid:PMC4832096
fatcat:l6rkd3lohbhovd76fcmn7txqgu
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... lescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using the Monetary Incentive Delay (MID) task. Behavioral performance was similar between groups. Group differences in BOLD activation during target anticipation and feedback anticipation periods of the task were examined using whole-brain analyses, as were group differences in age effects. During both target anticipation and feedback anticipation, adolescents with BD, compared to adolescents without psychopathology, exhibited decreased engagement of frontal regions involved in cognitive control (i.e., dorsolateral prefrontal cortex). Healthy adolescents exhibited age-related decreases, while adolescents with BD exhibited age-related increases, in activity of other cognitive control frontal areas (i.e., right inferior frontal gyrus), suggesting altered development in the BD group. Longitudinal research is needed to examine potentially abnormal development of cognitive control during reward pursuit in adolescent BD and whether early therapeutic interventions can prevent these potential deviations from normative development.
BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity
[article]
2021
bioRxiv
pre-print
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Purpose: The solid tumor microenvironment (TME) drives T cell dysfunction and inhibits the effectiveness of immunotherapies such as chimeric antigen receptor-based T cell (CAR T) cells. Early data has shown that modulation of T cell metabolism can improve intratumoral T cell function in preclinical models. Experimental Design: We evaluated GPC3 expression in human normal and tumor tissue specimens. We developed and evaluated BOXR1030, a novel CAR T therapeutic co-expressing glypican-3
doi:10.1101/2021.11.17.469041
fatcat:2qzj72dpvffptawhwk6afoznsu
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... geted CAR and exogenous glutamic-oxaloacetic transaminase 2 (GOT2) in terms of CAR T cell function both in vitro and in vivo. Results: Expression of tumor antigen GPC3 was observed by immunohistochemical staining in tumor biopsies from hepatocellular carcinoma, liposarcoma, squamous lung cancer, and Merkel cell carcinoma patients. Compared to control GPC3 CAR alone, BOXR1030 (GPC3-targeted CAR T cell that co-expressed GOT2) demonstrated superior in vivo efficacy in aggressive solid tumor xenograft models, and showed favorable attributes in vitro including an enhanced cytokine production profile, a less-differentiated T cell phenotype with lower expression of stress and exhaustion markers, an enhanced metabolic profile and increased proliferation in TME-like conditions. Conclusions: Together, these results demonstrated that co-expression of GOT2 can substantially improve the overall antitumor activity of CAR T cells by inducing broad changes in cellular function and phenotype. These data show that BOXR1030 is an attractive approach to targeting select solid tumors. To this end, BOXR1030 will be explored in the clinic to assess safety, dose-finding, and preliminary efficacy (NCT05120271).
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